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Department of Retrovirology: Research Projects download Retrovirology Research Projects

Protocols, Completed Year Started Year Ended
RV068 - Phase I Safety and Immunogenicity of a  Recombinant Envelop Based Product in Thai Volunteers  with Early HIV Infection (aborted) 1992 1993
RV069 - Phase I Safety and Immunogenicity of a Recombinant Envelop Based Product in HIV Seronegative Thai Volunteers (aborted) 1992 1993
RV091 - The Natural History of HIV-1 Infection and Disease in Thailand 1992 2001
RV093 - Immunologic Characterization of a Cohort of HIV-1 Highly Exposed Persistently Seronegative (HEPS) Individuals in Northern Thailand 1993 1996
RV099 - Clinical Study Protocol V6P17: A Phase I Trial of Biocine HIV SF2 gp120/MF59 Vaccine in Seronegative Thai Volunteers 1995 1997
RV101 - Screening and Evaluation of Potential Volunteers for HIV-1 Vaccine Trials 1999 2001
RV102 - Study of Prevalence and Incidence for HIV-1 Infections Among Eligible Thai Men in the Royal Thai Army at Prachuap Khiri Khan 1994 1997
RV104 - Incidence of HIV-1 Infection in Persons Attending Anonymous Test Sites and STD Clinics in Thailand 1994 1997
RV105 - Feasibility Study for Vaccine Cohort Development: Factory Workers Lampang 1995 1998
RV106 - Feasibility Study for Vaccine Cohort Development: Community-Based Study in Phayao 1995 1998
RV109 - Evaluation of HIV-1 Viral Burden, Mucosal Immunity and Systemic Immunity in Maternal-Infant Transmission in Northern Thailand 1998 2000
RV110 - Evaluation of HIV Infection in Vaccine Trial Participants in Thailand Follow-up Vaccine Trials (aborted) 1999 2000
RV114 - A Phase I/II Double-blind, Placebo-controlled Study of the Chiron Biocine HIV Thai E gp120/MF59 Vaccine Administered Alone or Combined with the Chiron Biocine HIV SF2gp120 Antigen in Healthy HIV Seronegative Thai Adults V26/6P1 1993 1995
RV115 - Health Evaluation HIV Infected of Thai Men 4 to 6 years After Discharge from the Royal Thai Army (RTA) 1998 2003
RV118 - Evaluation of the Mucosal Virology and Immunology of HIV-1 in Thailand 1998 2003
RV121 - Incidence of HIV-1 Infection in Females Attending Family Planning Clinics in Rayong Province, Thailand 1996 2001
RV126 - Community Based Cohort Study of HIV-1 Incidence in Thailand WRAIR # 673 1994 2003
RV127 - Community Cohort Studies to Identify Appropriate Populations for HIV-1 Vaccine Efficacy Trials in Northern Thailand 1994 2003
RV132 - Phase I/II Trial of Pasteur Mérieux Connaught Live Recombinant ALVAC-HIV (vCP1521) Priming With Either Oligomeric gp160 TH023/LAI-DID or Chiron HIV Thai E (CM235) gp120 [+/- SF2 gp120] Boosting in Thai HIV-Seronegative Adults IND# 8590 2000 2002
RV133 - A Pilot Study of Scrub Typhus-Induced Immunoneutralization of the HIV-1 Virus 1999 2000
RV135 - A Phase I/II Trial of Pasteur Mérieux Connaught (PMC) Live Recombinant ALVAC-HIV (vCP1521) Priming With VaxGen gp120 B/E (AIDSVAX™ B/E) Boost in Thai HIV-Seronegative Adults NID #8795 2000 2002
RV140 - Screening and Evaluation of Potential Volunteers for HIV-1 Vaccine Trials in Thailand (aborted)    
RV144 - A phase 3 trial of Aventis Pasteur live recombinant ALVAC HIV (vCP1521) priming with Vaxgen gp120 B/E (AIDSVAX B/E) Boosting HIV uninfected Thai adults IND #8795 2003 2009
RV148 - Screening protocol for the phase 3 vaccine trial 2003 2006
RV156 - VRC-HIVDNA009-VP (Multiclade HIV-1 DNA Plasmid Vaccine) 2005 2008
RV158 - A Phase I Double-Blind, Randomized, Dose Escalating, Placebo-Controlled, Study of Safety and Immunogenicity of WRAIR/NIH Live Recombinant MVACMDR (HIV-1 CM235 env/ CM240 gag/pol) Administered by Intramuscular (IM) or Intradermal (ID) Route In HIV Uninfected Adults 2005 2008
RV172 - A Phase 2 Clinical Trial to Evaluate the Safety and Immunogenicity of a Multicade HIV-1 DNA Plasmid, VRCHIVDNA016-00-VP, Boosted by Multicade HIV-1 Recombinant Adenovirus-5 Vaccine, VRC-HIV ADV014-00-VP in HIV Uninfected Adult Volunteers in East Africa 2007 2009
RV174 - The Effect of the HLA B46 Allele on the Natural History and Progression of HIV-1 Infection in Thailand 2007 2010
RV181 Randomized, Double Blind HIV Vaccine Trial to Evaluate the Immune Profile of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaXGen gp120 B/E (AIDSVAX® B/E) Boosting in HIV-uninfected Thai Adults (aborted)    
RV188 New laboratory techniques for the evaluation of the cellular and humoral immunity in HIV-Infected and non-infected Thai Individuals to HIV antigens and HIV vaccine reagents (aborted)    
RV225 - Molecular Epidemiology (Genotyping and Sequencing) of HIV from High-risk Client at an Anonymous Testing Clinic 2007 2009
RV233 (SEARCH 08) - Development of High-risk HIV Vaccine Preparatory Cohort at Thai Red Cross 2008 2010
RV250 - Multi-region Hybridization Assay Adaptation, Automation and Validation Using Dried Blood Spots for the Surveillance of HIV-1 Strains in South and Southeast Asia 2010 2011
WR # 1161 (SEARCH001) - Predictors of Neuro-cognitive Decline and Survival in HIV-infected Subjects (UH-PMK NeuroAIDS Study 001) 2006 2007
WR # 1307 (SEARCH 004) - Preliminary study of early primary HIV infection in high risk cohort 2006 2007
WR # 1708 - Comparative Study of FcR-Mediated Antibody Effector Assays for HIV-1 2010 2010

Protocols, Currently Implemented Year Started
RV152 - Extended evaluation of the virologic, immunologic, and clinical course of volunteers who become HIV-1 infected during participation in a phase III vaccine trial of ALVAC-HIV and AIDSVAX® B/E 2005
RV209 - Immunological assessment of RV135, A phase I/II of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaxGen 120 B/E (AIDSVAX B/E) Boosting in Thai-Seronegative Adults, using recently validated immuno-monitoring assays 2006
RV212 (IAVI Protocol G) - A cross-sectional study to screen for generate broadly neutralizing monoclonal antibodies from HIV Infected Individuals 2007
RV217d - Study of Prevalence and Incidence of HIV Among High-risk Volunteers in East Africa and Thailand (Pattaya) 2009
RV237 - Development and Characterization of Reagents for Studies of HIV-1 Neutralization from Archived Cell and Plasma Samples 2008
RV238 (SEARCH 007) - HIV-1 Specific Immune Responses in Thai Individuals with HIV Dementia 2008
RV243 - Assessment of Neutralizing Antibody in Participants from Phase I/II Trials of ALVAC-HIV (vCP-1521) Priming with Chiron gp12-B/E, Sanofi-Pasteur Oligomeric gp160, or AIDSVAX™ B/E gp120 B/E Boosting Against a Newly Developed, Standardized Panel of HIV-1 Isolates 2008
RV254 (SEARCH010) - Establish and Characterize an Acute HIV Infection Cohort in a Thai High Risk Population SEARCH Studies 2009
RV262 - A Phase I study of the safety and immunogenicity of PENNVAX G DNA (env, gag, pol) with IL-15 DNA plasmid adjuvant administered by Intramuscular Biojector® 2000 injection followed by intramuscular MVA-CMDR (HIV-1 CM235 env/ CM240 gag/pol) boost in healthy, HIV uninfected adults 2011
RV269-003 - HCV 2010
RV269-006 - To determine the concentration, characterization, and neutralizing activity of mucosal and plasma antibodies from RV118/HSRRB Log #A-7856 2009
RV322 - Humoral Immunological assessment of RV135, a phase I/II of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaxGen 120 B/E (AIDSVAX B/E) Boosting in Thai HIV-Seronegative Adults 2011
WR # 1498 (SEARCH 011) - Peripheral Reservoir of HIV DNA in Monocytes Pivotal to Cognition in HIV 2009
WR # 1505 (CDC # 4614) - HIV-1 Molecular Epidemiology in the Bangkok Men who have sex with Men (MSM) cohort study 2009
WR # 1587 - Study of full-length and partial HIV genetic sequences in seroconverting blood donors collected during September 2007-March 2008 2009
WR # 1617 - Characterization of humoral neutralizing activity in plasma of HIV individuals 2010
RV304 - Characteristics of immune cells in gut mucosa of HIV negative and chronically HIV-infected Thais 2012
RV305 - • RV305Randomized, Double Blind Evaluation of Late Boost Strategies for HIV-uninfected Participants in the HIV Vaccine Efficacy Trial RV144: Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaxGen gp120 B/E (AIDSVAX® B/E) Boosting in HIV-uninfected Thai Adults 2012

Protocols, Future Planned
RV217 Rapid Vax  Randomized, Double Blind Evaluation of Sanofi Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming and Global Solutions for Infectious Diseases (GSID) gp120 B/E (AIDSVAX® B/E) in an Accelerated Prime-Boost Regimen in HIV-uninfected Men who Have Sex with Men in Thailand
RV274 - Specimen Collection Procedures for Clinical Laboratory Quality Management Practices (Submitted to IRB)
RV306 - Randomized, Double Blind Evaluation of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming and Multiple Boosting Regimens with and without VaxGen gp120 B/E (AIDSVAX® B/E) in HIV-uninfected Thai Adults (Submitted for Scientific Review)
RV307 A Phase I Study of Prime-Boost Combinations Using Modified Vaccinia Ankara and Adenovirus Type 26 Vectors With Mosaic and Natural Inserts in Healthy, HIV-Uninfected Adults
RV310 - Randomized, Double Blind Evaluation of KI-DNA prime with MVA-CMDR boost in HIV-infected Thai Adults receiving HAART during acute phase infection - RV254 patients on mega HAART getting MVA vaccine (aborted)
RV320 - Quality of life assessment of HIV-infected volunteers, blood test result disclosure, and opinions of RV152 volunteers about the HIV vaccine trial result (Submitted for Scientific Review)
RV328 - Randomized, Double Blind Evaluation of Sequential Administrations of gp120 B/E (AIDSVAX® B/E) (GSID) with 1-Year Boosting in HIV-uninfected Thai Adults (Submitted for Scientific Review)
RV335 - Determination of the Quality, Quantity and Specificity of Antibodies in Mucosal Specimens Collected by the Thai Red Cross (Submitted to IRB)
RV348 - Longitudinal Study among Men who have Sex with Men at Risk for HIV-1 Infection to Determine Feasibility as a Cohort for a Future HIV Vaccine Trial 
WR#1896 - Surveillance of HIV resistance transmission and new HIV recombinant forms in Thailand      
WR#1912 - Molecular Characterization of HIV-1 in Female Sex Workers in Thailand
WR# 1921- Medical Quality Assurance on the Performance of HIV-1 Diagnostic Assays and HIV-1 Characterization
SEARCH 015 A Cohort Observational Study Evaluating Predictors, Incidence And Immunopathogenesis Of Immune Reconstitution Syndrome (IRIS) In HIV-1 Infected Patients With CD4 Count <100 Cells/µL Who Are Initiating Antiretroviral Therapy 

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Retrovirology Project Status


Chronology of Protocols: Type [click on the image to view the full-sized image]

Chronology of Protocols, Type

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Recent Activities at AFRIMS
AFRIMS recent activities HIV Vaccine Study First to show effectiveness AFRIMS on Dengue at Voice of America AFRIMS on Malaria in New York Times AFRIMS researchers instructed 104 medical cadets from Phramongkutklao College of Medicine AFRIMS hosts infectious diseae surveillance workshop for laos PDR lab technicians AFRIMS concludes Pilat Malaria Prophylaxis clinical trial in Cambodia Dr. Rampa Rattanarathiul received the Belkin Award, The highest honor given by the AMCA Dedication and opening of joint AFPMC AFRIMS molecular laboratory in the Phillippines NBC shows story on drug resistant malaria on the Thai-Cambodia border in Cambodia Malaria Vaccine: Inside look at first human trial from BBC news HVRC opening ceremony Change of Command 2015 AFRIMS leaders join "Bike For Mom 2015" event US Embassy Employee of the Month Public Release of Joint Concept of Health Services Public Release of Joint Concept of Health Services more AFRIMS activities